Hellboy and a rookie BPRD agent get stranded in 1950s rural Appalachia. There, they discover a small community haunted by witches, led by a local devil with a troubling connection to Hellboy’s past: the Crooked Man.
After the tragic overdose of his estranged friend, Will, a recovering addict, returns home, where he is reunited with Claire, his friend’s grieving mother, with whom he begins a secret but volatile affair.